Seminar - Optimal experimental design: a statistical tool for synthetic biology

The seminar will be given by Lucia Bandiera, EPSRC Research Fellow, The University of Edinburgh, UK

  • Date: 02 December 2019 from 09:00 to 11:00

  • Event location: Room 3.3, Cesena Campus, via dell'Università 50, Cesena (FC)

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Synthetic biology seeks to design biological parts and circuits that implement new functions in cells. Major accomplishments have been reported in this field, yet predicting a priori the in vivo behaviour of synthetic gene circuits is a major challenge. Mathematical models offer a means to address this bottleneck. However, in biology, modelling is perceived as an expensive, time-consuming task. Indeed, the quality of predictions depends on the accuracy of parameters, which are traditionally inferred from poorly informative data. Using model-based optimal experimental design (MBOED) provides a significant advantage in the identification of models of biological parts and should thus be integrated into their characterisation.